| Autor: |
Simoni, D., Giannini, G., Roberti, M., Rondanin, R., Baruchello, R., Rossi, M., Grisolia, G., Invidiata, F. P., Aiello, S., Marino, S., Cavallini, S., Siniscalchi, A., Gebbia, N., Crosta, L., Grimaudo, S., Abbadessa, V., Cristina, A. Di, Tolomeo, M. |
| Zdroj: |
Journal of Medicinal Chemistry; June 2005, Vol. 48 Issue: 13 p4293-4299, 7p |
| Abstrakt: |
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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