| Autor: |
Meier, Michael A. R., Aerts, Sebastianus N. H., Staal, Bastiaan B. P., Rasa, Mircea, Schubert, Ulrich S. |
| Zdroj: |
Macromolecular Rapid Communications; December 2005, Vol. 26 Issue: 24 p1918-1924, 7p |
| Abstrakt: |
Summary:A series of poly(ethylene glycol)‐block‐poly(ε‐caprolactone) diblock copolymers was synthesized and fully characterized. In particular, MALDI‐TOF MS results revealed interesting new insights into their molecular architecture. Small and defined micelles could be prepared from these block copolymers. Utilizing a high‐throughput screening approach, it was observed that these micelles are able to encapsulate/solubilize different guest molecules (e.g. drugs) depending on the solubility of the guest in water. Furthermore, it could be proven that a guest is located within a micelle and that these micelles can be utilized as transport vehicles for the encapsulated guest molecules. |
| Databáze: |
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