| Autor: |
Löster, Jana, Pretsch, Walter, Sandulache, Rodica, Schmitt-John, Thomas, Lyon, Mary F., Graw, Jochen |
| Zdroj: |
Genomics; September 1994, Vol. 23 Issue: 1 p240-242, 3p |
| Abstrakt: |
The murine dominant gene Cat-2was located on chromosome 1 between the loci of fuzzyand leaden. Subsequent linkage analysis revealed one recombinant between Cat-2tand isocitrate dehydrogenase-1, and one between Cat-2tand γE-crystallinamong 338 offspring in three-point backcrosses. The resulting genetic distance between the loci is 0.3 ± 0.3 cM. The very close linkage between the Cat-2and the γ-crystallingene cluster together with the finding of reduced γ-crystallin transcripts in mutant lenses suggest strongly that the γ-crystallingenes may be candidate genes for the Cat-2mutations. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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