| Autor: |
Ratner, Lee, Joseph, Theresa, Bandres, Juan, Ghosh, Sajal, Heyden, Nancy Vander, Templeton, Alan, Hahn, Beatrice, Powderly, William, Arens, Max |
| Zdroj: |
Virology; September 1996, Vol. 223 Issue: 1 p245-250, 6p |
| Abstrakt: |
Neftranscripts were analyzed from peripheral blood mononuclear cells of 10 HIV-1-infected subjects with 9-822 CD4+ lymphocytes/cu mm, including 4 individuals with a probable common source infection. There was no relationship between the phylogenetic position of the variousnefsequences and the disease state of the person from whom they were derived. Thenefopen reading frame was disrupted in all three clones from only 1 subject. Functional analyses of a representative clone from each of the remaining 9 subjects showed that allnefalleles were capable of CD4 cell surface down-regulation, but only threenefalleles suppressed the induction of IL-2 transcription. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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