| Autor: |
Nugent, T. C., Wakchaure, V. N., Ghosh, A. K., Mohanty, R. R. |
| Zdroj: |
Organic Letters; October 2005, Vol. 7 Issue: 22 p4967-4970, 4p |
| Abstrakt: |
A new method for the one-pot asymmetric reductive amination of prochiral aliphatic ketones has been developed. The previously unexplored reagent combination of Ti(OiPr)4/Raney Ni/H2 in the presence of (R)- or (S)-α-methylbenzylamine provides good to excellent yield (76−90%) and diastereomeric excess (72−98%). The second step, hydrogenolysis, provides the corresponding primary amine in high yield (88−93%) and with uncompromised enantiomeric excess. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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