Dendrimeric Molecular Transporters:  Synthesis and Evaluation of Tunable Polyguanidino Dendrimers That Facilitate Cellular Uptake

Autor: Wender, P. A., Kreider, E., Pelkey, E. T., Rothbard, J., VanDeusen, C. L.
Zdroj: Organic Letters; October 2005, Vol. 7 Issue: 22 p4815-4818, 4p
Abstrakt: Nine fluorescently labeled structurally varied polyguanidino dendrimers based on diamino acid monomeric units were individually synthesized in an efficient, scalable sequence using a trifluoroacetamide protecting group−perguanidinylation strategy. While the dendrimers varied significantly in their ability to enter a human lymphocyte cell line, the best transporters out-performed an oligoarginine reference standard.
Databáze: Supplemental Index