| Autor: |
Xie, C., Staszak, M. A., Quatroche, J. T., Sturgill, C. D., Khau, V. V., Martinelli, M. J. |
| Zdroj: |
Organic Process Research & Development; November 2005, Vol. 9 Issue: 6 p730-737, 8p |
| Abstrakt: |
Nucleosidic phosphoramidites are key building blocks for the automated, solid supported syntheses of oligonucleotide-based drugs. A safe, industrially viable process for preparing nucleosidic phosphoramidites 5-Me-MOE-U and MOE-A has been developed and utilized on multikilogram scales. The optimization of this process is described in detail. Emphasis is placed on the search for activators to replace the hazardous 1H-tetrazole, the development of an extractive workup, and the advancement of a precipitation method to avoid both chromatographic purification and product foaming issues. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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