Carbohydrate-Bearing 3-Hydroxy-4-pyridinonato Complexes of Gallium(III) and Indium(III)

Autor: Green, D. E., Ferreira, C. L., Stick, R. V., Patrick, B. O., Adam, M. J., Orvig, C.
Zdroj: Bioconjugate Chemistry; November 2005, Vol. 16 Issue: 6 p1597-1609, 13p
Abstrakt: Gallium and indium complexes with pendant carbohydrates have been prepared and examined for their potential as radiopharmaceuticals. Carbohydrate-bearing 3-hydroxy-4-pyridinone ligand precursors and their tris(ligand)gallium(III) and -indium(III) complexes were synthesized and characterized by mass spectrometry, elemental analysis, and 1H and 13C NMR spectroscopy, and in the case of one intermediate, by X-ray crystallography. With three equivalents of ligand, neutral complexes formed with the bidentate hydroxypyridinone moiety complexing the gallium(III) and indium(III) metal centers.
Databáze: Supplemental Index