| Autor: |
Leung, T.F., Tang, N.L.S., Lam, C.W.K., Li, A.M., Fung, S.L.M., Chan, I.H.S., Wong, G.W.K. |
| Zdroj: |
Respiratory Medicine; February 2005, Vol. 99 Issue: 2 p216-219, 4p |
| Abstrakt: |
G-401A polymorphism in RANTESpromoter was associated with near-fatal asthma and atopic dermatitis in children. We studied whether gain-of-function mutations in RANTESgene were associated with asthma and atopy-related traits in Chinese children. Plasma total and aeroallergen-specific IgE concentrations were measured using micro-particle immunoassay and fluorescent enzyme immunoassay, respectively. Restriction fragment length polymorphism was used to genotype RANTESG-401A and C-28G. One hundred and twenty-nine asthmatic children and 66 controls were recruited. Their mean logarithmic plasma total IgE concentrations were 2.53 and 1.98, respectively (P<0.0001). RANTESG-401A was not associated with physician-diagnosed asthma (P=0.408). However, RANTES-401A allele was significantly associated with IgE sensitization to cat (odds ratio 2.35; 95% CI 1.15–4.77; P=0.010). Those homozygous for -401A had higher plasma cat-specific IgE levels (P=0.034). Subjects having -401A were also more likely to have mold-specific IgE (odds ratio 3.82; 95% CI 1.24–12.14; P=0.007). On spirometry, those with -401A/A had lower forced expiratory volume in 1-s (FEV1; P=0.044). RANTESC-28G was not associated with any outcome in this study. In conclusion, the gain-of-function mutation at -401 of RANTESpromoter is associated with sensitization to cat and mold allergens and FEV1in Chinese children. |
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