| Autor: |
Ajagbonna, O. P., Adegunloye, B. J., Sofola, O. A. |
| Zdroj: |
Journal of Herbs, Spices, & Medicinal Plants; December 1998, Vol. 6 Issue: 1 p37-42, 6p |
| Abstrakt: |
The bark extract of Rhaptopetalum coriaceum Olio was tested for relaxant effects on vascular smooth muscle using isolated rat aortic rings precontracted with 10-7 M noradrenaline. Relaxation experiments were also conducted on intact endothelium and on methylene blue treated, indomethacin treated, and denuded endothelium tissues. The extract induced a maximum relaxation response in control rings of 73 percent. This relaxation response was significantly attenuated by removal of the endothelium and by treatment with methylene blue where the maximum relaxations achieved were 24 and 15 percent, respectively. The relaxation response induced by Rhaptopetalum coriaceum extract was, however, not affected by indomethacin treatment. The relaxation response to the extract appears to occur by an endothelium dependent mechanism which may be linked to intracellular elevation of cyclic guanosine monophosphate (cGMP). |
| Databáze: |
Supplemental Index |
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