| Autor: |
An, S.Z., Yang, J.H., Xia, M.H., Goetzl, E.J. |
| Zdroj: |
Biochemical and Biophysical Research Communications; November 1993, Vol. 197 Issue: 1 p263-270, 8p |
| Abstrakt: |
Prostaglandin E2 (PGE2) is a potent mediator in many human tissues, that is recognized by three distinct subtypes of receptors, designated EP1, EP2 and EP3. A cDNA from a human lung library encodes a 53 kDa protein of 88% homology with the mouse EP2 receptor. Human EP2 receptors in COS-7 cell transfectants bound [3H]-PGE2 with a mean Kd of 2.2 nM and native specificity, and transduced increases in the intracellular concentration of cyclic AMP, but not of Ca++. That most EP2 receptor mRNA is in lung, kidney, intestinal, glandular and immune tissues, is consistent with functional responses. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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