| Autor: |
Koike, George, Vooren, Pascale Van, Shiozawa, Masahide, Galli, Joakim, Li, Luo-Sheng, Glaser, Anna, Balasubramanyam, Ashok, Brown, Laura J., Luthman, Holger, Szpirer, Claude, Macdonald, Michael J., Jacob, Howard J. |
| Zdroj: |
Genomics; November 1996, Vol. 38 Issue: 1 p96-99, 4p |
| Abstrakt: |
The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mtGPD) plays an important role in the regulation of insulin secretion and has been postulated as a candidate responsible for the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) in humans as well as in rodent models of NIDDM. Recent molecular genetic studies of the Goto–Kakizaki (GK) rat model of NIDDM have identified loci linked to NIDDM. To elucidate whether rat mtGPD might play a role in the pathogenesis of NIDDM, the rat mtGPD gene (Gpd2) was cloned, and a genetic marker forGpd2was developed. The gene mapped to the region of rat chromosome 3 that contains a region linked to NIDDM in the GK rat. Fluorescencein situhybridization was also carried out to verify the map position. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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