| Autor: |
Shemyakin, I., Pukhalsky, A., Stepanshina, V., Shmarina, G., Aleshkin, V., Afanas'ev, S. |
| Zdroj: |
Bulletin of Experimental Biology and Medicine; October 2005, Vol. 140 Issue: 4 p439-444, 6p |
| Abstrakt: |
We studied the effects of α1-acid glycoprotein preparations on the survival rate of BALB/c mice infected with the lethal dose of B. anthracis STI-1. Apart from native α1-acid glycoprotein from donor blood, we studied 3 glycoforms differing in the affinity for concanavalin A and structure of carbohydrate chains. The protective effect of α1-acid glycoprotein preparations did not depend on its dose and was observed 3 months after treatment (0.3 mg per mouse). The protective effect was revealed in mice receiving α1-acid glycoprotein preparations 2 h before infection and 24 h after inoculation of the bacterial culture. In the latter case the survival rate of animals was much higher compared to that observed in preventive administration of α1-acid glycoprotein. The protective effect practically did not depend on the time of treatment with glycoforms. Pretreatment with α1-acid glycoprotein preparations significantly decreased plasma interferon-γ concentration. Administration of the test preparations 24 h after infection decreased the concentration of tumor necrosis factor-α. |
| Databáze: |
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