| Autor: |
Malaisse, Willy J, Ladrière, Laurence, Laghmich, Aouatif, Louchami, Karim, Jijakli, Hassan, Viñambres, Concepción, Villanueva-Peñacarrillo, Maria L., Valverde, Isabel, Björkling, Fredrik |
| Zdroj: |
Biochemical and Molecular Medicine; October 1997, Vol. 62 Issue: 1 p76-84, 9p |
| Abstrakt: |
A novel ester of succinic acid, 1,2,3-tri(methylsuccinyl)glycerol ester (3SMG), was found to stimulate insulin release from rat pancreatic islets. In the presence of 7 mMd-glucose, a 10 μM concentration of 3SMG was sufficient to cause a significant increase in insulin output. The ester mimicked the effect of other nutrient secretagogues in enhancing the synthesis of islet peptides, with a preferential action on proinsulin as distinct from nonhormonal peptides, in decreasing86Rb outflow from prelabeled islets, and in stimulating Ca2+inflow into the islet cells. It is proposed, therefore, that 3SMG displays the attributes suitable for stimulation or potentiation of insulin release in noninsulin-dependent diabetes, without requiring administration in large amounts and, hence, without the risk of excessive hepatic gluconeogenesis. |
| Databáze: |
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