| Autor: |
Ozaki, M., Morii, H., Qvist, R., Watanabe, Y. |
| Zdroj: |
Biochemical and Biophysical Research Communications; November 1994, Vol. 205 Issue: 1 p12-17, 6p |
| Abstrakt: |
Treatment of the rat C6 glioma cell line with interleukin-1β (IL-1β) resulted in an accumulation of cytosolic phospholipase A2(cPLA2) in mRNA level. The increase of cPLA2in mRNA level was observed at 6 hours after treatment of IL-1β and reached to the maximal level at 12 hours. The accumulation also remained sustained for up to 72 hours. Dose response curve of IL-1β showed that as little as 40 units/ml concentration induced the accumulation of mRNA and 100 units/ml concentration showed the maximal effect. In contrast, cyclooxygenase 2 gene was not affected with treatment of IL-1β. |
| Databáze: |
Supplemental Index |
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