Phospholipase A2 Is Activated by Tumor Necrosis Factor-α in Primary Hepatocytes Stimulated by a Deleted Form of Hepatocyte Growth Factor

Autor: Georgakopoulos, E., Mcmenamin, M., Skouteris, G.G.
Zdroj: Biochemical and Biophysical Research Communications; December 1995, Vol. 217 Issue: 3 p1263-1270, 8p
Abstrakt: Several factors are released in the liver microenvironment immediately after injury. Among these factors TNFα is implicated as a regulator of hepatocyte proliferation. Hepatocytes in the intact liver are mostly in the G0phase of the cell cycle and after injury (including collagenase perfusion) display a constitutive expression of the growth-regulated c-myconcogene. TNFα co-added with dHGF in hepatocyte cultures, superinduced the DNA synthetic response observed at all time points. In parallel, TNFα/dHGF-treated hepatocytes have shown increased expression of the c-myconcogene at times corresponding to the in vitro G1phase of the cell cycle. TNFα activated PLA2 in hepatocytes and it is believed that the subsequent production of PGE2 plays a role in the "priming" proccess in these cells and at the same time amplifies the proliferating signals induced by hepatocyte-specific growth factors.
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