The total synthesis of (–)-α-kainic acid using titanium-mediated diene metallabicyclisation methodology

Autor: D. Campbell, Andrew, J. K. Taylor, Richard, M. Raynham, Tony
Zdroj: Chemical Communications; February 7, 1999, Vol. 1999 Issue: 3 p245-246, 2p
Abstrakt: Titanium-mediated diene metallabicyclisation–elimination–functionalisation has been utilised for the preparation of syn-3,4-disubstituted and syn,syn-2,3,4-trisubstituted pyrrolidines in high yield and excellent stereoselectivity; this methodology has been employed in a total synthesis of (–)-α-kainic acid starting from L-serine.
Databáze: Supplemental Index