An Integrated Genetic and Man–Mouse Comparative Map of theDXHXS674–Pdha1Region of the Mouse X Chromosome

Autor: Blair, Helen J., Uwechue, Ifeanyi C., Barsh, Gregory S., Rowe, Peter S.N., Boyd, Yvonne
Zdroj: Genomics; February 1998, Vol. 48 Issue: 1 p128-131, 4p
Abstrakt: The genes for ocular albinisim type 1 (OA1) and theXenopus laevis-like apical protein (APXL) map between amelogenin (AMELX) and the pseudoautosomal boundary in the distal region of the human X chromosome short arm. The mouse homologues,Oa1andApxl,have recently been shown to lie proximal to their expected locations on the mouse X chromosome, but their positions with respect to critical gene loci in the vicinity have not been defined. By analyzing recombination events from (Mus musculus×Mus spretus) ×M. musculusbackcrosses, we have constructed a detailed mouse genetic map that encompassesOa1,five other genes, and 13 microsatellite loci. The order of genes and evolutionary breakpoints (EB) is defined as centromere–(EB)–(DXHXS674, DXHXS679)–Smcx–(EB)–Oa1–(EB)–Phex(3′ → 5′)–Pdha1–telomere. ThusOa1lies in a region between two previously characterized conserved segments.
Databáze: Supplemental Index
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