| Autor: |
Lee, Richard L., Johnson, Kenneth R., Lerner, Terry J. |
| Zdroj: |
Genomics; August 1996, Vol. 35 Issue: 3 p617-619, 3p |
| Abstrakt: |
We describe the isolation and chromosomal mapping of a mouse homolog of the Batten disease gene,CLN3.Like its human counterpart, the mouse cDNA contains an open reading frame of 1314 bp encoding a predicted protein product of 438 amino acids. The mouse and human coding regions are 82 and 85% identical at the nucleic acid and amino acid levels, respectively. The mouse gene maps to distal Chromosome 7, in a region containing genes whose homologs are on human chromosome 16p12, whereCLN3maps. Isolation of a mouseCLN3homolog will facilitate the creation of a mouse model of Batten disease. |
| Databáze: |
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