| Autor: |
Wilkins, J., Lyttle, D., Sivananthan, K., El-Gabalawy, H. |
| Zdroj: |
Cellular Immunology; February 1993, Vol. 146 Issue: 2 p313-323, 11p |
| Abstrakt: |
The interactions of lymphocytes with cultured synovial cells derived from rheumatoid arthritis patients were examined. A number of lymphoid cell lines bound to these cells. The adherence of several of these lines was inhibited by antibodies to fibronectin. The adherence of the T cell leukemia Jurkat was sensitive to inhibition by antibodies to the fibronectin receptors α4β1 and α5β1. The adherence of the β1 integrin negative B cell line RPMI 8866 was inhibited by antibodies to the vitronectin receptor, αvβ3. The interactions of several other cell lines with synovial cells appeared to be independent of this fibronectin-dependent pathway. These results indicate that multiple potential adhesion pathways for cellular interactions in the tissues may exist. The adherence to cell-associated fibronectin may play a contributory role in such processes for certain lymphocyte subsets. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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