| Autor: |
Klivenyi, Peter, Matthews, Russell T., Wermer, Marieke, Yang, Lichuan, MacGarvey, Usha, Becker, David A., Natero, Reina, Beal, M.Flint |
| Zdroj: |
Experimental Neurology; July 1998, Vol. 152 Issue: 1 p163-166, 4p |
| Abstrakt: |
Azulenyl nitrones are a unique class of free radical spin-trapping compounds. We administered both a water-soluble and a lipid-soluble azulenyl nitrone to mice prior to administration of MPTP. Both compounds produced significant neuroprotection against depletions of dopamine and its metabolites measured 1 week after MPTP administration. There were no effects on MPP+levels. These findings provide further evidence that free radical scavengers can produce significant neuroprotection against MPTP neurotoxicity. |
| Databáze: |
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