| Autor: |
Kosawada, Tadashi, Konno, Ken-ichi, Yamamura, Shingo, Kanazawa, Toshikatsu |
| Zdroj: |
Microsystem Technologies; August 2005, Vol. 11 p943-949, 7p |
| Abstrakt: |
Abstract In this study, a new method of noninvasive sensor system is developed to detect mechanical stresses induced in minute living cells and tissues. The bending mode of vibration, excited impulsively by piezoelectric ceramics, is utilized in a small clamped-free beam type vibrator which is mounted on micromanipulator system. Experimental studies have been carried out by using living egg cell of killifish and also three dimensionally tissue-engineered regenerated cartilage. The method has shown enough capabilities as a micro-sensor to detect mechanical stresses which are environmentally induced in living cells. Also, it has suggested a possibility to provide useful information to decide whether three dimensionally cultured cartilage tissue has enough biomechanical properties for transplantation treatment of damaged cartilage. |
| Databáze: |
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