| Autor: |
Jikko, Akitoshi, Wakisaka, Takashi, Iwamoto, Masahiro, Hiranuma, Hiroko, Kato, Yukio, Maeda, Takashi, Fujishita, Masami, Fuchihata, Hajime |
| Zdroj: |
Cell Biology International; September 1998, Vol. 22 p615-621, 7p |
| Abstrakt: |
Interleukin-6 (IL-6) levels are markedly increased in the synovial fluid of patients with rheumatoid arthritis or osteoarthritis. However, the effects of IL-6 on proliferation and proteoglycan metabolism in articular cartilage are not known. We demonstrated here the effects of human recombinant (hr) IL-6 on proliferation and proteoglycan metabolism in rabbit articular chondrocyte cultures.In vitro, these cells proliferated and produced abundant extracellular matrices. We found that 1–10ng/ml of hrIL-6 inhibited proliferation to approximately 65% of control levels and suppressed colony formation induced by bFGF in soft agarose. The same concentration of hrIL-6 depressed proteoglycan synthesis to approximately 60% of control levels. Moreover, hrIL-6 significantly enhanced proteoglycan degradation induced by hrIL-1β, although hrIL-6 alone did not affect proteoglycan degradation. These findings suggest that IL-6 is a negative regulator for chondrocyte proliferation and articular cartilage metabolism. |
| Databáze: |
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