Highly selective O-phosphitylation of amino alcohols using PIIIreagents containing 4-nitro and 2,4-dinitro aryloxy leaving groupsElectronic Supplementary Information ESI available. Experimental conditions and characterisation of all presented compounds. See DOI: 10.1039/b509150k

Autor: Dabkowski, Wojciech, Ozarek, Alfred, TworowskaPermanent address: Department of Biochemistry, Izabela, Biology, Cell, University, Rice, MS-140, 61
Zdroj: New Journal of Chemistry; 2005, Vol. 29 Issue: 11 p1396-1399, 4p
Abstrakt: A method for direct highly O-selective phosphitylation of amino alcohols by reagents containing a 4-nitrophenoxy or 2,4 dinitrophenoxy leaving group has been developed. This method provides mild reaction conditions to access O-phosphitylated amino alcohols. The flexibility of the synthesis is exemplified by the models of simple amino alcohols and of nucleosides containing unprotected NH2groups.
Databáze: Supplemental Index