Autor: |
Motameni, Amir-Reza T., Juncadella, Ignacio J., Ananthanarayanan, Shobana K., Hedrick, Michael N., Huet-Hudson, Yvette, Anguita, Juan |
Zdroj: |
Infection and Immunity; June 2004, Vol. 72 Issue: 6 p3638-3642, 5p |
Abstrakt: |
ABSTRACTA Salmonella entericaserovar Typhimurium aroA-deficient delivery system was used to target the immunosuppressive protein Salp15 to antigen-presenting cells. In vitro and in vivo infections with Salp15-containing Salmonellaresulted in an impaired CD4+-T-cell activation, suggesting that the protein was produced by antigen-presenting cells in a physiologically active form. |
Databáze: |
Supplemental Index |
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