| Autor: |
Jeddeloh, J A, Fritz, D L, Waag, D M, Hartings, J M, Andrews, G P |
| Zdroj: |
Infection and Immunity; January 2003, Vol. 71 Issue: 1 p584-7, 4p |
| Abstrakt: |
A whole-body mouse model of pneumonic melioidosis was established for future evaluation of biodefense vaccine candidates. The aerosol 50% lethal doses of Burkholderia pseudomallei strain 1026b for BALB/c and C57BL/6 mice and the times to death, dissemination in organs, and tissue loads after exposure of the mice to low- and high-dose aerosols are reported. In addition, rpsL mutant backgrounds were attenuated in this acute model of disease. |
| Databáze: |
Supplemental Index |
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