Production of macrophage inflammatory protein 3alpha (MIP-3alpha) (CCL20) and MIP-3beta (CCL19) by human peripheral blood neutrophils in response to microbial pathogens.

Autor: Akahoshi, Tohru, Sasahara, Takeshi, Namai, Rie, Matsui, Toshimichi, Watabe, Hiroyuki, Kitasato, Hidero, Inoue, Matsuhisa, Kondo, Hirobumi
Zdroj: Infection and Immunity; January 2003, Vol. 71 Issue: 1 p524-6, 3p
Abstrakt: Effects of bacterial pathogens on the production of macrophage inflammatory protein 3alpha (MIP-3alpha) and MIP-3beta from human peripheral blood neutrophils were investigated. Neutrophils produced both chemokines by coincubation with either gram-positive or gram-negative bacteria. Neutrophils may initiate antigen-specific immune responses through the release of these chemokines that are capable of promoting selective recruitment of dendritic cells and T-cell subsets.
Databáze: Supplemental Index