Nicotinamide ribosyl uptake mutants in Haemophilus influenzae.
Autor: | Herbert, Mark, Sauer, Elizabeta, Smethurst, Graeme, Kraiss, Anita, Hilpert, Anna-Karina, Reidl, Joachim |
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Zdroj: | Infection and Immunity; September 2003, Vol. 71 Issue: 9 p5398-401, 4p |
Abstrakt: | The gene for the nicotinamide riboside (NR) transporter (pnuC) was identified in Haemophilus influenzae. A pnuC mutant had only residual NR uptake and could survive in vitro with high concentrations of NR, but could not survive in vivo. PnuC may represent a target for the development of inhibitors for preventing H. influenzae disease. |
Databáze: | Supplemental Index |
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