Nasal immunization with homogenate and peptide antigens induces protective immunity against Trichinella spiralis.

Autor: McGuire, Carolann, Chan, Weng C, Wakelin, Derek
Zdroj: Infection and Immunity; December 2002, Vol. 70 Issue: 12 p7149-52, 4p
Abstrakt: Mice were successfully immunized against the intestinal nematode Trichinella spiralis by intranasal administration of a 30-mer peptide antigen with cholera toxin B. Immunized mice developed antigen-specific serum immunoglobulin G1, intestinal immunoglobulin A, and a type 2-biased cytokine response. Intranasal immunization therefore generates the Th2-mediated responses required for immunity against intestinal parasites.
Databáze: Supplemental Index