| Autor: |
Wesson, C A, Deringer, J, Liou, L E, Bayles, K W, Bohach, G A, Trumble, W R |
| Zdroj: |
Infection and Immunity; May 2000, Vol. 68 Issue: 5 p2998-3001, 4p |
| Abstrakt: |
In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection. |
| Databáze: |
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