Increased capacity for interleukin-2 synthesis parallels disease progression in mice infected with Leishmania major.

Autor: Heinzel, F P, Rerko, R M, Hujer, A M, Maier, R A
Zdroj: Infection and Immunity; September 1998, Vol. 66 Issue: 9 p4537-40, 4p
Abstrakt: Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon deficiency. However, IL-2 mRNA levels in vivo did not reflect IL-2 production in vitro. Because IL-2 contributes to the pathogenesis of progressive leishmaniasis, the functional significance of these findings should be further explored.
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