Inhibition of class II major histocompatibility complex antigen processing by Escherichia coli heat-labile enterotoxin requires an enzymatically active A subunit.

Autor: Matousek, M P, Nedrud, J G, Cieplak, W, Harding, C V
Zdroj: Infection and Immunity; July 1998, Vol. 66 Issue: 7 p3480-4, 5p
Abstrakt: Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT) were found to inhibit intracellular antigen processing. Processing was not inhibited by mutant LT with attenuated ADP-ribosyltransferase activity, CT B or LT B subunit, which enhanced presentation of preexisting cell surface peptide-class II major histocompatibility complex complexes. Inhibition of antigen processing correlated with A subunit ADP-ribosyltransferase activity.
Databáze: Supplemental Index