| Autor: |
Shearer, M H, Lucas, A H, Anderson, P W, Carey, K D, Jenson, H B, Chanh, T C, Stanley, J R, Kennedy, R C |
| Zdroj: |
Infection and Immunity; August 1997, Vol. 65 Issue: 8 p3267-70, 4p |
| Abstrakt: |
These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated mothers failed to respond to a single immunization with unconjugated Hib PRP. Specific Hib PRP immunoglobulin G (IgG) but not IgM antibodies cross the baboon placenta and are detected in the offspring. Higher-titer baboon anti-Hib PRP did not express two previously defined cross-reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expression. Spectrotype analysis indicated that baboon anti-Hib PRP was restricted in heterogeneity and oligoclonal. |
| Databáze: |
Supplemental Index |
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