Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae.

Autor: Solnick, J V, Josenhans, C, Suerbaum, S, Tompkins, L S, Labigne, A
Zdroj: Infection and Immunity; September 1995, Vol. 63 Issue: 9 p3718-21, 4p
Abstrakt: Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.
Databáze: Supplemental Index