| Autor: |
Vries, Jan E. de, Punnonen, Juha, Cocks, Benjamin G., Aversa, Gregorio |
| Zdroj: |
Seminars in Immunology; December 1993, Vol. 5 Issue: 6 p431-439, 9p |
| Abstrakt: |
Induction of immunoglobulin (Ig) isotype switching and isotype production by human B cells requires contact-mediated signals delivered by T helper cells in combination with cytokines. Effective T cell help requires T cell activation resulting in a rapid expression of T cell membrane proteins, which interact with ligands constitutively expressed on B cells. These interactions lead to B cell activation, proliferation and, in the presence of cytokines, to isotype switching and immunoglobulin synthesis. The nature of the T cell antigens involved in these T/B cell interactions, and their role in human B cell activation resulting in IgE synthesis in the presence of IL-4 and IL-13, will be discussed. Copyright 1993, 1999 Academic Press |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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