| Autor: |
Falk, Rama, Grunwald, Jacob, Hoffman, Amnon, Domb, Abraham J., Polacheck, Itzhack |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; September 2004, Vol. 48 Issue: 9 p3606-3609, 4p |
| Abstrakt: |
ABSTRACTThe pharmacokinetic characteristics and tissue distribution of a novel water-soluble, nontoxic amphotericin B-arabinogalactan (AMB-AG) conjugate exhibited distinct differences from those of micellar and liposomal amphotericin B formulations. These differences included extended persistence of drug in the body and its accumulation in the lungs; thus, the AMB-AG conjugate was highly effective in treating systemic murine aspergillosis. |
| Databáze: |
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