| Autor: |
Pasca, Maria Rosalia, Guglierame, Paola, Arcesi, Fabio, Bellinzoni, Marco, De Rossi, Edda, Riccardi, Giovanna |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; August 2004, Vol. 48 Issue: 8 p3175-3178, 4p |
| Abstrakt: |
ABSTRACTThe Mycobacterium tuberculosisRv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatiscells containing the Rv2686c-Rv2687c-Rv2688c operon was observed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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