| Autor: |
Goldstein, Cathy, Lee, Margie D., Sanchez, Susan, Hudson, Charlene, Phillips, Brad, Register, Brad, Grady, Michael, Liebert, Cynthia, Summers, Anne O., White, David G., Maurer, John J. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; March 2001, Vol. 45 Issue: 3 p723-726, 4p |
| Abstrakt: |
ABSTRACTMany pathogenic and commensal organisms are multidrug resistant due to exposure to various antibiotics. Often, this antimicrobial resistance is encoded by integrons that occur on plasmids or that are integrated into the bacterial chromosome. Integrons are commonly associated with bacterial genera in the familyEnterobacteriaceae. We determined that class 1 integrases were present in approximately 46% of the isolates from the familyEnterobacteriaceae; class 2 integrases were present only among Escherichia coliand Salmonellaisolates. Seven percent of veterinary isolates were positive for class 3 integrase by DNA-DNA hybridization but could not be confirmed to be positive by PCR. None of the veterinary isolates possessed the class 4 integrase gene. The distribution of these integrase genes was variable within the members of the family Enterobacteriaceaewhen some or all integrase classes were absent from a particular genus. There was also considerable variability in the distribution of these integrases within a species, depending on the animal host. Unlike the class 1 integrases, the other integrase class, intI2, appears to be more restricted in its distribution among the members of the family Enterobacteriaceae. There is also considerable variability in the distribution of the class 1 integrases withinE. colistrains isolated from different food animals. The class 1 integrases are the most widely disseminated of the four classes among the members of the family Enterobacteriaceaefrom both the clinical and normal flora of animals. This is the first report to closely examine the distribution of class 2 integrases in members of the family Enterobacteriaceaeisolated in the United States. |
| Databáze: |
Supplemental Index |
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