| Autor: |
Pérez-Trallero, E., Fernández-Mazarrasa, C., Garcı́a-Rey, C., Bouza, E., Aguilar, L., Garcı́a-de-Lomas, J., Baquero, F. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; December 2001, Vol. 45 Issue: 12 p3334-3340, 7p |
| Abstrakt: |
ABSTRACTA nationwide multicenter susceptibility surveillance study which included 1,684 Streptococcus pneumoniaeand 2,039S. pyogenesisolates was carried out over 1 year in order to assess the current resistance patterns for the two most important gram-positive microorganisms responsible for community-acquired infections in Spain. Susceptibility testing was done by a broth microdilution method according to National Committee for Clinical Laboratory Standards M100-S10 interpretative criteria. ForS. pneumoniae, the prevalences of highly resistant strains were 5% for amoxicillin and amoxicillin-clavulanic acid; 7% for cefotaxime; 22% for penicillin; 31% for cefuroxime; 35% for erythromycin, clarithromycin, and azithromycin; and 42% for cefaclor. For S. pyogenes, the prevalence of erythromycin resistance was 20%. Efflux was encountered in 90% of S. pyogenesand 5% of S. pneumoniaeisolates that exhibited erythromycin resistance. Erythromycin resistance was associated with clarithromycin and azithromycin in both species, regardless of phenotype. Despite the different nature of the mechanisms of resistance, a positive correlation (r= 0.612) between the two species in the prevalence of erythromycin resistance was found in site-by-site comparisons, suggesting some kind of link with antibiotic consumption. Regarding ciprofloxacin, the MIC was ≥4 μg/ml for 7% of S. pneumoniaeand 3.5% of S. pyogenesisolates. Ciprofloxacin resistance (MIC, ≥4 μg/ml) was significantly (P< 0.05) associated with macrolide resistance in both S. pyogenesand S. pneumoniaeand with penicillin nonsusceptibility in S. pneumoniae. |
| Databáze: |
Supplemental Index |
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