| Autor: |
Polonio, Roy E., Mermel, Leonard A., Paquette, Gregory E., Sperry, Jay F. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; November 2001, Vol. 45 Issue: 11 p3262-3266, 5p |
| Abstrakt: |
ABSTRACTStaphylococcus epidermidisis a major cause of infections associated with indwelling medical devices. Biofilm production is an important virulence attribute in the pathogenesis of device-related infections. Therefore, elimination of these biofilms is an ideal treatment. Salicylate (5 mM) combined with 1 μg of vancomycin per ml inhibited biofilm formation by S. epidermidis(RP62A) by ≥99.9%. When biofilm-coated polystyrene beads were exposed to 5 mM sodium salicylate and 4 μg of vancomycin per ml (one-half the minimum biofilm eradication concentration), there was a >99.9% reduction in viable count. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
