| Autor: |
Kalfa, V. C., Jia, H. P., Kunkle, R. A., McCray, P. B., Tack, B. F., Brogden, K. A. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; November 2001, Vol. 45 Issue: 11 p3256-3261, 6p |
| Abstrakt: |
ABSTRACTSMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were not as active as the parent molecules. With immunoelectron microscopy, SMAP29 was seen on membranes and within the cytoplasm of Pseudomonas aeruginosaPAO1. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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