Treatment of Vancomycin-Resistant Enterococcal Infections in the Immunocompromised Host: Quinupristin-Dalfopristin in Combination with Minocycline

Autor: Raad, Issam, Hachem, Ray, Hanna, Hend, Girgawy, Essam, Rolston, Kenneth, Whimbey, Estella, Husni, Rola, Bodey, Gerald
Zdroj: Antimicrobial Agents and Chemotherapy; November 2001, Vol. 45 Issue: 11 p3202-3204, 3p
Abstrakt: ABSTRACTBetween February 1994 and November 1998, 56 oncology patients infected with vancomycin-resistant enterococci (VRE) were treated with quinopristin-dalfopristin (Q-D) plus minocycline (MIN). Infections included bacteremia, urinary tract infection, pneumonia, and wound infection. The response rate was 68%, and the most frequent adverse event was arthralgia or myalgia (36%). Q-D–MIN is effective for VRE infection in cancer patients but is associated with a substantial frequency of arthralgia or myalgia.
Databáze: Supplemental Index