Influence of Carbon Dioxide on the MIC of Telithromycin for Streptococcus pneumoniae: an In Vitro-In Vivo Study

Autor: Batard, Eric, Juvin, Marie Emmanuelle, Jacqueline, Cédric, Bugnon, Denis, Caillon, Jocelyne, Potel, Gilles, Drugeon, Henri B.
Zdroj: Antimicrobial Agents and Chemotherapy; January 2005, Vol. 49 Issue: 1 p464-466, 3p
Abstrakt: ABSTRACTIncubation in CO2resulted in higher (≥3 doubling dilution) MICs of telithromycin than those found in ambient air for 31.2% of 346 Streptococcus pneumoniae ermB-positive strains. An increased telithromycin MIC in CO2was not correlated with loss of its activity in the murine sepsis/peritonitis model.
Databáze: Supplemental Index