Physical Analysis of the Region Deleted in thetw18Allele of the Mousetcl-4Complementation Group

Autor: Barclay, Jane, King, Timothy F., Crossley, Philip H., Barnard, Richard C., Larin, Zoia, Lehrach, Hans, Little, Peter F.R.
Zdroj: Genomics; August 1996, Vol. 36 Issue: 1 p39-46, 8p
Abstrakt: We have generated a YAC contig of at least 3.3 Mb from the proximal region ofIn(17)4of mouse chromosome 17. This region corresponds to DNA lost in the gastrulation mutanttw18,which belongs to thetcl-4complementation group. Our most proximal and distal probes lie within the deletion—3.3 Mb apart—indicating that we have not cloned the entire region. The deleted region is contained in a genetic interval of less than 1 cM, suggesting that some suppression of recombination must occur.
Databáze: Supplemental Index