Lehualides A−D, Metabolites from a Hawaiian Sponge of the Genus Plakortis

Autor: Sata, N., Abinsay, H., Yoshida, W. Y., Horgen, F. D., Sitachitta, N., Kelly, M., Scheuer, P. J.
Zdroj: Journal of Natural Products; September 2005, Vol. 68 Issue: 9 p1400-1403, 4p
Abstrakt: A collection of an undescribed marine sponge of the genus Plakortis yielded four new “polyketide-derived” metabolites, lehualides A−D (14). The structures of compounds 14 were elucidated by interpretation of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.
Databáze: Supplemental Index