Localization of the Tight Junction Protein Gene TJP1 to Human Chromosome 15q13, Distal to the Prader-Willi/Angelman Region, and to Mouse Chromosome 7

Autor: Mohandas, T. K., Chen, X.-N., Rowe, L. B., Birkenmeier, E. H., Fanning, A. S., Anderson, J. M., Korenberg, J. R.
Zdroj: Genomics; December 10, 1995, Vol. 30 Issue: 3 p594-597, 4p
Abstrakt: The gene encoding the tight junction (zonula occludens) protein, TJP1, was mapped to human chromosome 15q13 by fluorescence in situ hybridization (FISH) using a cDNA probe. The Jackson Laboratory backcross DNA panel derived from the cross (C57BL/6JEi × SPRET/Ei) F1 females × SPRET/Ei males was used to map the mouse Tjp1 to chromosome 7 near position 30 on the Chromosome Committee Map, a region with conserved homology to human chromosome 15q13. FISH studies on metaphases from patients with the Prader-Willi (PWS) or the Angelman syndrome (AS) showed that TJP1 maps close but distal to the PWS/AS chromosome region. Copyright 1995, 1999 Academic Press
Databáze: Supplemental Index
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