| Autor: |
Barone, K.Siobhan, Jain, Shilpa L., Michael, J.Gabriel |
| Zdroj: |
Cellular Immunology; June 1995, Vol. 163 Issue: 1 p19-29, 11p |
| Abstrakt: |
The role of CD8+and CD4+cells in the generation and maintenance of high-dose oral tolerance has been investigated. Mice depleted of CD8+cells prior to or subsequent to oral tolerization with OVA continued to express suppressed humoral and/or T cell proliferative responses to the homologous antigen. To assess the effect of CD4+cell depletion on oral tolerance, mice were depleted of CD4+cells prior to or subsequent to oral tolerization with OVA. After 50% regeneration of CD4+cells was achieved, OVA-immunized mice produced anti-OVA immune responses that were comparable to those of water-fed control mice. Thus, under our experimental conditions the presence of CD4+but not CD8+cells is required to both establish and maintain oral tolerance. |
| Databáze: |
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