The Nitric Oxide Donor SIN-1 Protects Endothelial Cells from Tumor Necrosis Factor-α-Mediated Cytotoxicity: Possible Role For Cyclic GMP and Heme Oxygenase

Autor: Polte, Tobias, Oberle, Stefanie, Schröder, Henning
Zdroj: Journal of Molecular and Cellular Cardiology; December, 1997, Vol. 29 Issue: 12 p3305-3310, 6p
Abstrakt: In cultured endothelial cells, incubation with TNF-α(50 ng/ml) for 72 h markedly reduced viability of endothelial cells. A 6-h pre-incubation with the nitric oxide (NO) donor linsidomine (SIN-1, 10–150μ
Databáze: Supplemental Index