| Autor: |
Winkelman, D L B, Beck, C L, Ypey, D L, O'leary, M E |
| Zdroj: |
The Journal of Pharmacology and Experimental Therapeutics; September 2005, Vol. 314 Issue: 3 p1177-86, 10p |
| Abstrakt: |
n-Butyl-p-aminobenzoate (BAB; butamben) is a long-duration anesthetic used for the treatment of chronic pain. Epidural administration of BAB is thought to reduce the electrical excitability of dorsal root nociceptor fibers by inhibiting voltage-gated ion channels. To further investigate this mechanism, we examined the effects of BAB on the potassium currents of acutely dissociated neurons from the rat dorsal root ganglion (DRG). These neurons express a rapidly inactivating A-type K(+) current (I(A)) that is resistant to tetraethylammonium (20 mM) but inhibited by 4-aminopyridine (5 mM). At low concentrations, BAB (
|
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
