| Autor: |
Crimmins, M. T., McDougall, P. J., Emmitte, K. A. |
| Zdroj: |
Organic Letters; September 2005, Vol. 7 Issue: 18 p4033-4036, 4p |
| Abstrakt: |
A stereoselective synthesis of the BCDE fragment of brevetoxin A has been completed. anti-Glycolate aldol, glycolate alkylation, and ring-closing metathesis reactions were employed as key bond-forming events. A convergent assembly strategy was employed that relied on a Horner−Wadsworth−Emmons union of two complex fragments. Subsequent cyclization and dehydration led to efficient generation of an intermediate endocyclic enol ether, which was advanced to a tetracyclic fragment. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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